Enterovirus Survey in Children after Mass Vaccination with Live Attenuated Polioviruses

Enterovirus survey in children after mass vaccination with live attenuated polioviruses.

CORRESPONDENCE R.S.P.C.A. Campaign. C. W. HUME, M.C., B.Sc. ....................... 790 Vaccination and Leukaemia. E. DAVIDSON, M.R.C.P., and F. G. J. HAYHOE, M.D. ..... ........... 790 Reactions to Smallpox Vaccination. W. J. MCLEOD, M.D., D.P.H., and J. A. GILMORE, M.B., D.P.H.; J. P. C. M. BROOKES, L.M.S.S.A., and J. R. P. GIBBONS, F.R.C.S.Ed.; C. TAYLOR, M.B. 790 Vaccination Against Smallpo...

Immune responses after live attenuated influenza vaccination

Since 2003 (US) and 2012 (Europe) the live attenuated influenza vaccine (LAIV) has been used as an alternative to the traditional inactivated influenza vaccines (IIV). The immune responses elicted by LAIV mimic natural infection and have been found to provide broader clinical protection in children compared to the IIVs. However, our knowledge of the detailed immunological mechanisims induced by...

Mass immunization of children in Iran with live attenuated Sugiyama measles virus adapted to calf kidney cell cultures

Longevity of B-Cell and T-Cell Responses After Live Attenuated Influenza Vaccination in Children

BACKGROUND The live attenuated influenza vaccine (LAIV) is the preferred vaccine for children, but the mechanisms behind protective immune responses are unclear, and the duration of immunity remains to be elucidated. This study reports on the longevity of B-cell and T-cell responses elicited by the LAIV. METHODS Thirty-eight children (3-17 years old) were administered seasonal LAIV. Blood sam...

Boosting of Cross-Reactive and Protection-Associated T Cells in Children After Live Attenuated Influenza Vaccination

Background. Live attenuated influenza vaccines (LAIVs) stimulate a multifaceted immune response including cellular immunity, which may provide protection against newly emerging strains. This study shows proof of concept that LAIVs boost preexisting, cross-reactive T cells in children to genetically diverse influenza A virus (IAV) strains to which the children had not been exposed. Methods. We...